Tinnitus and Ulixy CBD Neon Cubes

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Name of treatment	Ulixy CBD Neon Cubes
Type of treatment	Pharmaceutical
Claims for treatment	“Stress, depression, anxiety, and other problems like inflammation and chronic pain can be easily reduced”[1]
How treatment is delivered	Small gummie sweets. Claims to contain “a high amount of proteins and vitamins”[2] with the “main ingredient” being CBD oil[3]
Potential negative consequences	Animal models suggest that cannabinoids may promote the development of tinnitus[4] [5]. Users of marijuana are more likely to experience tinnitus[6]
Evidence offered:
Papers available	10 relevant papers found with keywords tinnitus + cannabinoid in PubMed database
Conclusions drawn	To date, there have been no systematic studies of the effects of cannabinoids on tinnitus in humans.[7] It is feasible that different cannabinoids may have different effects on tinnitus.[8]
Quality of evidence[9]	C/D
Does the BTA recommend this treatment?	No
BTA opinion on this treatment:	Very little research has been done, but the evidence so far suggests that cannabinoids may exacerbate tinnitus. Licences for the use of CBD oil or hemp oil as a medicine have not yet been granted.
Would the BTA support further studies into this treatment?	Yes, if high quality study.
Verdict: Safety - is this treatment harmful?	Evidence of harm
Verdict: Efficacy - does this treatment work?	Evidence that it has no effect
Comments	Products containing CBD oil are legal in the UK, providing the content of a psychoactive component of cannabis (THC, tetrahydrocannabinol) is 0.2% or below.

 

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[1] NK Enterprises. Ulixy CBD Neon Cubes: #1 CBD Gummies Reviews 2021 SCAM or LEGIT? https://www.mynewsdesk.com/n-k-enterprises/pressreleases/ulixy-cbd-neon-cubes-number-1-cbd-gummies-reviews-2021-scam-or-legit-3114580 [accessed 6 September 2021]

[2] ibid

[3] ibid

[4]  Zheng Y, Reid P, Smith PF. Cannabinoid CB1 receptor agonists do not decrease, but may increase acoustic trauma-induced tinnitus in rats. Frontiers in Neurology 2015. https://doi.org/10.3389/fneur.2015.00060

[5] Narwani V, Bourdillon A, Nalamada K, Manes RP, Hildrew DM. Does cannabis alleviate tinnitus? A review of the current literature. Laryngoscope Investigative Otolaryngology. 2020 Oct 30;5(6):1147-1155. doi: 10.1002/lio2.479. 

[6] Qian ZJ, Alyono JC. An Association between marijuana use and tinnitus. American Journal of Otolaryngology. 2020; 41(1): 102314. doi:10.1016/j.amjoto.2019.102314

[7] Smith PF, Zheng Y. Cannabinoids, cannabinoid receptors and tinnitus. Hearing Research, 2016; 332 210-216.

[8] Narwani V, Bourdillon A, Nalamada K, Manes RP, Hildrew DM. Does cannabis alleviate tinnitus? A review of the current literature. Laryngoscope Investigative Otolaryngology. 2020 Oct 30;5(6):1147-1155. doi: 10.1002/lio2.479. 

[9] A = Systematic review/meta analysis. B = Randomised control studies. C = Cohort studies. D = Case control studies. E = case studies/reports. +/- to be used to indicate quality within bands

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TINNITUS AND ULIXY CBD NEON CUBES

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Image is of gummie sweets and is not intended to be an accurate representation of the product.

Updated 8 October 2021