Tinnitus and Zenzi CBD Gummies

Name of treatment

Zenzi CBD Gummies

Does the BTA recommend this treatment?

No

BTA opinion on this treatment:

Very little research has been done, but the evidence so far suggests that cannabinoids may exacerbate tinnitus.

Licences for the use of CBD oil or hemp oil as a medicine have not yet been granted.

Type of treatment

Pharmaceutical

Claims for treatment

“Decrease stress and help with other health difficulties”[1]

How treatment is delivered

Small gummie sweets. Gummies contain 100% organic hemp oil [2] and 300mg of organic hemp extract[3]

Potential negative consequences

Animal models suggest that cannabinoids may promote the development of tinnitus[4] [5].

Users of marijuana are more likely to experience tinnitus[6]

Evidence offered:

 

Papers available

10 relevant papers found with keywords tinnitus + cannabinoid in PubMed database

Conclusions drawn

To date, there have been no systematic studies of the effects of cannabinoids on tinnitus in humans.[7] It is feasible that different cannabinoids may have different effects on tinnitus.[8]

Quality of evidence[9]

C/D

Would the BTA support further studies into this treatment?

Yes, if high quality study.

Verdict: Safety - is this treatment harmful?

  Evidence of harm

Verdict: Efficacy - does this treatment work?

  Evidence that it has no effect

Comments

Products containing CBD oil are legal in the UK, providing the content of a psychoactive component of cannabis (THC, tetrahydrocannabinol) is 0.2% or below.

Completed by

Nic Wray

Peer reviewed by

 

Date completed

September 2021

Date for revision

September 2024

 

We welcome feedback on all our information. Please send any corrections or updates for consideration to Nic Wray, Communications Manager on [email protected]

 

[1] Zenzi CBD Gummies. Zenzi CBD Gummies – Shark Tank, Benefits, Review and Where To Buy.

https://sites.google.com/view/zenzi-cbd-gummies-info/

[2] ibid

[3] ibid

[4]  Zheng Y, Reid P, Smith PF. Cannabinoid CB1 receptor agonists do not decrease, but may increase acoustic trauma-induced tinnitus in rats. Frontiers in Neurology 2015. https://doi.org/10.3389/fneur.2015.00060

[5] Narwani V, Bourdillon A, Nalamada K, Manes RP, Hildrew DM. Does cannabis alleviate tinnitus? A review of the current literature. Laryngoscope Investigative Otolaryngology. 2020 Oct 30;5(6):1147-1155. doi: 10.1002/lio2.479. 

[6] Qian ZJ, Alyono JC. An Association between marijuana use and tinnitus. American Journal of Otolaryngology. 2020; 41(1): 102314. doi:10.1016/j.amjoto.2019.102314

[7] Smith PF, Zheng Y. Cannabinoids, cannabinoid receptors and tinnitus. Hearing Research, 2016; 332 210-216.

[8] Narwani V, Bourdillon A, Nalamada K, Manes RP, Hildrew DM. Does cannabis alleviate tinnitus? A review of the current literature. Laryngoscope Investigative Otolaryngology. 2020 Oct 30;5(6):1147-1155. doi: 10.1002/lio2.479. 

[9] A = Systematic review/meta analysis. B = Randomised control studies. C = Cohort studies. D = Case control studies. E = case studies/reports. +/- to be used to indicate quality within bands

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TINNITUS AND ZENZI CBD GUMMIES

Image by Alexas_Fotos on Pixabay.

Image is of gummie sweets and is not intended to be an accurate representation of the product.

Updated 27 May 2021